Batsakis J G, Solomon A R, Rice D H
Head Neck Surg. 1980 Sep-Oct;3(1):43-57. doi: 10.1002/hed.2890030110.
Neoplasms of the supporting tissues in the head and neck are outnumbered by their histologic counterparts in the trunk and extremities. This is especially true for tumors of bone, cartilage, and the remnants of the notochord. Malignancies occurring in all three tissues, however, are just as lethal as those sited elsewhere. Chondrosarcomas and osteogenic sarcomas of the facial bones are resistant to all conventional modes of therapy, manifest many recurrences, and have an often protracted morbidity. The craniocervical chordoma manifests a similar biologic course. For the tumors of cartilaginous origin and the osteogenic sarcomas, the initial surgical attempt at removal is of key importance. Neoplasms present at the margins of resection have a poor prognosis. Chorodomas are not likely to be cured by any modality.
头颈部支持组织肿瘤的数量比躯干和四肢中组织学上对应的肿瘤数量少。对于骨、软骨和脊索残余肿瘤来说尤其如此。然而，这三种组织中发生的恶性肿瘤与其他部位的恶性肿瘤一样致命。面骨的软骨肉瘤和成骨肉瘤对所有传统治疗方式均耐药，多次复发，且发病过程常常迁延。颅颈交界区脊索瘤表现出相似的生物学过程。对于软骨源性肿瘤和成骨肉瘤，最初的手术切除尝试至关重要。切除边缘存在的肿瘤预后不良。脊索瘤不太可能通过任何治疗方式治愈。
