Sell S, Stillman D, Gochman N
Am J Clin Pathol. 1976 Nov;66(5):847-53. doi: 10.1093/ajcp/66.5.847.
The serum concentrations of alpha-fetoprotein of rats following experimental galactosamine-induced liver-cell necrosis accurately reflect the severity of preceding liver-cell damage as determined by elevation of serum transaminases. There is a very close correlation between the highest SGOT or SGPT serum activity found 1-2 days after induction of necrosis and the subsequent elevation of alpha-fetoprotein at 2-6 days. Elevations of alpha-fetoprotein are associated in time with restitutive proliferation of the damaged liver. These experimental results clarify the temporal relationship between alpha-fetoprotein and repair of liver-cell damage, which has been suggested by similar observations in cases of patients who have acute or sub-acute viral hepatitis. The correlations support the concept that serum alpha-fetoprotein concentrations may be used as a prognostic indicator of the extent and course of fulminatn or subacute hepatitis.
实验性半乳糖胺诱导大鼠肝细胞坏死后，血清甲胎蛋白浓度能准确反映先前肝细胞损伤的严重程度，这一损伤程度由血清转氨酶升高来确定。坏死诱导后1至2天测得的最高血清谷草转氨酶或谷丙转氨酶活性与随后2至6天甲胎蛋白的升高之间存在非常密切的相关性。甲胎蛋白的升高在时间上与受损肝脏的修复性增殖相关。这些实验结果阐明了甲胎蛋白与肝细胞损伤修复之间的时间关系，这一关系在急性或亚急性病毒性肝炎患者的类似观察中也有所提示。这些相关性支持了血清甲胎蛋白浓度可作为暴发性或亚急性肝炎的程度和病程的预后指标这一概念。
