血清甲胎蛋白浓度升高与肝硬化肝脏假性梗死相关：病例报告

High serum alpha-fetoprotein concentration associated with pseudoinfarction of a cirrhotic liver: report of a case.

作者信息

Matsushita K, Tanabe G, Aikou T, Hamanoue M, Sakoda M, Yoshinaka H, Yoshida A, Yoshida H, Matsumoto T

机构信息

First Department of Surgery, School of Medicine, Kagoshima University, Japan.

出版信息

Surg Today. 1996;26(10):818-21. doi: 10.1007/BF00311644.

DOI:10.1007/BF00311644

PMID:8897683

Abstract

We report herein the case of a 65-year-old man with cirrhosis of the liver in whom a portal vein thrombus was found to be the cause of a marked elevation in serum alpha-fetoprotein (AFP). The patient presented with fever and abdominal pain, and a diagnostic work-up revealed a liver mass and an increased serum AFP concentration of 91,000 ng/ml. The mass gradually regressed, and the AFP concentration simultaneously decreased to 163 ng/ml. However, because hepatocellular carcinoma (HCC) could not be ruled out, a partial hepatectomy was performed. Histological examination of the resected specimen revealed a thrombus of the portal vein surrounded by the fibrosis associated with liver cirrhosis, but no neoplastic lesion was found. Thus, portal thrombus associated with liver cirrhosis might induce an extremely high level of AFP production.

摘要

我们在此报告一例65岁肝硬化男性患者，发现门静脉血栓是血清甲胎蛋白（AFP）显著升高的原因。患者表现为发热和腹痛，诊断性检查发现肝脏肿块，血清AFP浓度升高至91,000 ng/ml。肿块逐渐消退，AFP浓度同时降至163 ng/ml。然而，由于不能排除肝细胞癌（HCC），遂行部分肝切除术。切除标本的组织学检查显示门静脉血栓被与肝硬化相关的纤维化所包围，但未发现肿瘤性病变。因此，与肝硬化相关的门静脉血栓可能诱导产生极高水平的AFP。