α-甲胎蛋白与中毒性肝损伤

alpha-Fetoprotein in toxic liver injury.

作者信息

Smuckler E A, Koplitz M, Sell S

出版信息

Cancer Res. 1976 Dec;36(12):4558-61.

Abstract

The temporal sequence of alpha-fetoprotein appearance in serum was determined in both necrogenic and nonnecrogenic liver injury. Ethionine, thioacetamide, and CCl4 were used to intoxicate male and female rats for evaluating serum enzyme levels, mitotic indices, and morphological reflections of impairment. Thioacetamide- and CCl4-induced cell death preceded the mitotic wave in residual hepatocytes, and, in the case of both agents, this intoxicant-mediated necrosis preceded the emergence of alpha-fetoprotein. Yet, although there was no evidence of either cell destruction or significant mitotic activity in ethionine-poisoned animals, serum alpha-fetoprotein levels progressively increased. Thus the temporal sequence of alpha-fetoprotein synthesis and/or release and cellular reorganization for regeneration suggests that reappearance of the protein macro-molecule is an expression of the altered phenotype observed during the "step-down" phase of liver regeneration.

摘要

在致坏死性和非致坏死性肝损伤中均测定了血清中甲胎蛋白出现的时间顺序。用乙硫氨酸、硫代乙酰胺和四氯化碳使雄性和雌性大鼠中毒，以评估血清酶水平、有丝分裂指数和损伤的形态学表现。硫代乙酰胺和四氯化碳诱导的细胞死亡先于残余肝细胞中的有丝分裂波，并且对于这两种药物，这种由毒物介导的坏死先于甲胎蛋白的出现。然而，尽管在乙硫氨酸中毒的动物中没有细胞破坏或明显有丝分裂活性的证据，但血清甲胎蛋白水平却逐渐升高。因此，甲胎蛋白合成和/或释放以及细胞重组以进行再生的时间顺序表明，这种蛋白质大分子的重新出现是在肝再生“降调”阶段观察到的表型改变的一种表现。