Marks H L, Siegel H S
Poult Sci. 1980 Aug;59(8):1700-5. doi: 10.3382/ps.0591700.
Two lines of Japanese quail were divergently selected for high and low plasma cholesterol levels after three daily injections with 2 IU of adrenocorticotropen (ACTH)/100 g of body weight. Plasma cholesterols were obtained at 31 days of age, just before the first injection, and at 34 days of age, after the last injection. After eight generations of selection, the plasma cholesterol level after ACTH injections in the high line was 34% greater than the level in the control line, whereas the low line level was approximately 14% less than that in the control. Selection differentials were significantly greater in the high line than in the low line. The realized heritability for plasma cholesterol before ACTH treatment calculated by regression of progeny on mid-parent was .25 in the high line and .16 in the low line.
对两行日本鹌鹑进行了定向选育，在每天给每100克体重注射2国际单位促肾上腺皮质激素（ACTH），连续注射三天后，使其血浆胆固醇水平分别升高或降低。在31日龄（首次注射前）和34日龄（末次注射后）采集血浆胆固醇样本。经过八代选育后，高选育系在注射ACTH后的血浆胆固醇水平比对照系高34%，而低选育系的水平比对照系低约14%。高选育系的选择差显著大于低选育系。通过子代对中亲值的回归计算得出，ACTH处理前血浆胆固醇的实际遗传力在高选育系中为0.25，在低选育系中为0.16。
