Schechter M D
Pharmacol Biochem Behav. 1980 Aug;13(2):307-9. doi: 10.1016/0091-3057(80)90091-x.
Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Apomorphine, at doses different than the training dose, produced a dose-response relationship, whereas, caffeine (7.5-30 mg/kg) produced saline-like responding. However, co-administered of 15 mg/kg caffeine with 0.01, 0.02 or 0.04 mg/kg apomorphine potentiated the discriminative stimulus properties of these low apomorphine doses. This potentiation was antagonized by pretreatment with 0.25 mg/kg haloperidol. The results are consistent with the idea that caffeine, by virtue of being a phosphodiesterase inhibitor, may increase post-synaptic cyclic-AMP and this, in turn, may supersensitize the dopamine receptors and result in the potentiation of the apomorphine-induced dopaminergic responses.
在一项双杠杆、以食物为动机的操作性任务中，训练大鼠区分腹腔注射0.16 mg/kg阿扑吗啡和生理盐水的刺激特性。与训练剂量不同的阿扑吗啡剂量产生了剂量-反应关系，而咖啡因（7.5 - 30 mg/kg）产生了类似生理盐水的反应。然而，15 mg/kg咖啡因与0.01、0.02或0.04 mg/kg阿扑吗啡共同给药增强了这些低剂量阿扑吗啡的辨别刺激特性。这种增强作用被0.25 mg/kg氟哌啶醇预处理所拮抗。结果与以下观点一致，即咖啡因作为一种磷酸二酯酶抑制剂，可能会增加突触后环磷酸腺苷，进而可能使多巴胺受体超敏，并导致阿扑吗啡诱导的多巴胺能反应增强。
