Katrak S M, Pollock M, O'Brien C P, Nukada H, Allpress S, Calder C, Palmer D G, Grennan D M, McCormack P L, Laurent M R
Brain. 1980 Sep;103(3):671-93. doi: 10.1093/brain/103.3.671.
Three cases of gold-related neuropathy are reported. Clinical features include an acute, symmetrically progressive polyneuropathy, focal or generalized myokymia and a tendency for initial neurological deterioration followed by improvement, after cessation of chrysotherapy. The degree of clinical recovery related to maximal disability. Morphological findings on sural nerve biopsies revealed both axonal degeneration and segmental remyelination. Similar peripheral nerve histology was seen in a parallel animal study in which the severity of the neuropathy was dose-related.
报告了3例与金相关的神经病变。临床特征包括急性、对称性进行性多发性神经病变、局灶性或全身性肌纤维颤搐，以及在停止金疗法后，神经功能最初恶化随后改善的趋势。临床恢复程度与最大残疾程度相关。腓肠神经活检的形态学结果显示既有轴突变性又有节段性髓鞘再生。在一项平行的动物研究中观察到了类似的周围神经组织学变化，其中神经病变的严重程度与剂量相关。
