Weller R O, Bruckner F E, Chamberlain M A
J Neurol Neurosurg Psychiatry. 1970 Oct;33(5):592-604. doi: 10.1136/jnnp.33.5.592.
Peripheral nerves in five patients with rheumatoid neuropathy were examined electrophysiologically and by sural nerve biopsy. There was close correlation between the clinical severity of the disease and the degree of nerve damage found histologically and by EMG. Group 1 patients with a mild distal sensory neuropathy showed varying degrees of axonal degeneration in the large myelinated fibres and some segmental demyelination. Group 2 patients with a severe, rapidly progressive sensori-motor neuropathy had extensive loss of myelinated fibres. In one case all the large fibres had degenerated. The second case had lost both large and small myelinated fibres together with many of the non-myelinated axons. The major nerve damage in both groups appeared to be axonal degeneration but some segmental demyelination was detected. Occlusive vascular disease in the vasa nervorum was considered to be the major cause of the nerve damage.
对5例类风湿性神经病变患者的周围神经进行了电生理检查和腓肠神经活检。疾病的临床严重程度与组织学及肌电图检查发现的神经损伤程度之间存在密切相关性。第1组轻度远端感觉神经病变患者的大髓鞘纤维出现不同程度的轴索变性和一些节段性脱髓鞘。第2组严重、快速进展的感觉运动神经病变患者有广泛的髓鞘纤维丧失。1例所有大纤维均已变性。第2例大小髓鞘纤维均丧失，同时许多无髓鞘轴突也丧失。两组的主要神经损伤似乎都是轴索变性，但也检测到一些节段性脱髓鞘。神经滋养血管的闭塞性血管疾病被认为是神经损伤的主要原因。
