Johnson R W, Reisine T, Spotnitz S, Wiech N, Ursillo R, Yamamura H I
Eur J Pharmacol. 1980 Oct 3;67(1):123-7. doi: 10.1016/0014-2999(80)90019-9.
The effects of yohimbine on desipramine-induced adrenoreceptor alterations were examined in murine limbic forebrain areas. Treatment with both drugs in combination resulted in a significant decrease in [3H]dihydroalprenolol binding, which was not manifest after treatment with either drug alone. Moreover, co-administration of yohimbine was found to accelerate the time course and increase the magnitude of desipramine-induced increases in [3H]clonidine binding. The possible physiologic significance of these findings is discussed along with their pharmacologic implications.
在小鼠边缘前脑区域研究了育亨宾对去甲丙咪嗪诱导的肾上腺素能受体改变的影响。联合使用这两种药物进行治疗导致[3H]二氢阿普洛尔结合显著减少，而单独使用任何一种药物治疗后均未出现这种情况。此外，发现联合使用育亨宾可加速时间进程，并增加去甲丙咪嗪诱导的[3H]可乐定结合增加的幅度。讨论了这些发现可能的生理意义及其药理学意义。
