Pace-Asciak C R, Edwards N S, Carrara M C
Experientia. 1980 Jun 15;36(6):635-7. doi: 10.1007/BF01970104.
Tritium-labeled PGF2 alpha was administered i.v. into rats of varying ages (2, 4, 6 weeks and adult). Urine was collected and assayed for radioactive products by thin-layer-chromatography. Results showed a distinctly different urinary profile between the 2-week-old and the adult rat. While the urinary pattern from the 2-week-old rat gave a single less polar product than PGF2 alpha, the pattern from the adult rat gave products more polar than PGF2 alpha. Urine from the 4- and 6-week-old rats gave a mixture of these types of products. These results indicate that some prostaglandin catabolic pathway (likely the omega-oxidative system) is activated in vivo within the 4-6 week postnatal period in the rat.
将氚标记的前列腺素F2α静脉注射到不同年龄（2周、4周、6周和成年）的大鼠体内。收集尿液，通过薄层色谱法测定放射性产物。结果显示，2周龄大鼠和成年大鼠的尿样谱明显不同。2周龄大鼠的尿样模式产生了一种比前列腺素F2α极性更小的单一产物，而成年大鼠的尿样模式产生的产物比前列腺素F2α极性更大。4周龄和6周龄大鼠的尿液产生了这些类型产物的混合物。这些结果表明，大鼠出生后4 - 6周内，体内某些前列腺素分解代谢途径（可能是ω-氧化系统）被激活。
