Pace-Asciak C R, Edwards N S
J Biol Chem. 1980 Jul 10;255(13):6106-10.
Seven urinary catabolites were identified after intravenous infusion of tritium-labeled prostaglandin F2 alpha in the adult rat. Most products were the result of oxidation at C-15, reduction of the delta 13,14 double bond, and double beta oxidation together with omega oxidation reactions yielding 14 and 16 carbon compounds. While the former sequence of reactions is also demonstrable in the neonate (2 weeks and older), the omega oxidation system develops around 28 to 32 days of age. Consequently, the urinary catabolic pattern resulting from infusion of tritiated prostaglandin F2, in the rat younger than 32 days is composed principally of one product identified as 15-keto-13,14-dihydrotetranor prostaglandin F2 alpha (VII). This product is one of the transient intermediates in the adult and is catabolized further by omega oxidation.
在成年大鼠静脉注射氚标记的前列腺素F2α后，鉴定出了7种尿代谢产物。大多数产物是C-15位氧化、δ13,14双键还原、双β氧化以及ω氧化反应共同作用的结果，生成了含14和16个碳原子的化合物。虽然前一反应序列在新生大鼠（2周及以上）中也能得到证实，但ω氧化系统在约28至32日龄时发育成熟。因此，在32日龄以下的大鼠中，注射氚标记的前列腺素F2后产生的尿分解代谢模式主要由一种鉴定为15-酮-13,14-二氢四降前列腺素F2α（VII）的产物组成。该产物是成年动物中的一种瞬时中间体，并通过ω氧化进一步分解代谢。
