Gräfe U, Steudel A, Bocker H, Thrum H
Z Allg Mikrobiol. 1980;20(3):185-94. doi: 10.1002/jobm.3630200305.
o-Aminobenzoic acid (OABA) known by its stimulatory effect on streptothricin biosynthesis by Streptomyces noursei JA 3890b was found to suppress specifically the formation of cytochrome a-type terminal oxidase while the levels of the b- and c-type cytochromes apparently remained unaffected. This change was coupled to decreased capacity of transport of u-14C-L-alanine and u-14C-L-glutamic acid into the mycelium, giving rise to delay of amino acid catabolism and decreased production of nitrogen catabolites within the cell. The above results provide supporting evidence for conjectures recently published by us concerning the control by nitrogen catabolites of the secondary metabolism of this strain. As a summary a scheme is proposed showing several hypothetic mechanisms by which nitrogen catabolite regulation of nourseothricin production could be accomplished.
邻氨基苯甲酸（OABA）因对诺尔斯链霉菌JA 3890b的链丝菌素生物合成具有刺激作用而闻名，它被发现能特异性抑制细胞色素a型末端氧化酶的形成，而b型和c型细胞色素的水平显然不受影响。这种变化与将14C-L-丙氨酸和14C-L-谷氨酸转运到菌丝体中的能力下降有关，导致氨基酸分解代谢延迟，细胞内氮分解代谢产物的产生减少。上述结果为我们最近发表的关于该菌株次级代谢受氮分解代谢物控制的推测提供了支持证据。作为总结，提出了一个方案，展示了几种可能实现氮分解代谢物对诺尔丝菌素生产调控的假设机制。
