磷酸盐对诺尔斯链霉菌JA 3890b生物合成制霉菌素的影响。
Effect of phosphate on the biosynthesis of nourseothricin by Streptomyces noursei JA 3890b.
作者信息
Müller P J, Haubold G, Menner M, Grosse H H, Ozegowski J H, Bocker H
出版信息
Z Allg Mikrobiol. 1984;24(8):555-64.
The results present evidence for the important role of phosphate-mediated regulation of the nourseothricin biosynthesis by the processes of phosphate limitation and release of phosphate. Also, higher initial concentrations of phosphate were found to have a strong inhibitory effect on the biosynthesis of nourseothricin. It is concluded that the initial phosphate concentration was the primary target for the biometrical optimization of the fermentation medium. The presence of zinc ions neutralized the negative effect of high initial concentrations of phosphate which was also strongly influenced by the regime of sterilization.
结果表明，磷酸盐通过磷酸盐限制和释放过程介导对诺尔丝菌素生物合成的调节作用具有重要意义。此外，还发现较高的初始磷酸盐浓度对诺尔丝菌素的生物合成具有强烈的抑制作用。得出的结论是，初始磷酸盐浓度是发酵培养基生物量优化的主要目标。锌离子的存在抵消了高初始磷酸盐浓度的负面影响，而这种影响也受到灭菌方式的强烈影响。
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