Atiyeh M, Ali M A
Am J Gastroenterol. 1980 Jul;74(1):25-9.
A high incidence of primary hepatocelluar carcinoma in the Orient and Africa has been reported. It is also seen frequently in Saudi Arabia. In a series of 54 consecutive patients diagnosed histologically, the male to female ratio was 10:1--the highest reported. The peak age was between 40-60 years and the mean survival was eight months. This is in contrast to hepatocelluar carcinoma in Africa where the age is between 25-35 years and the disease runs a quick downhill course simulating an abscess. Macronodular cirrhosis was diagnosed histologically or suggested clinically in 80% of the cases. Serum was positive for HBsAg in 55% of the patients, compared with 8% in healthy blood donors. These figures are as significant as reports from high incidence areas and point strongly to a possible causal relationship between HBV infection and the development of primary hepatocellular carcinoma.
据报道，原发性肝细胞癌在东方和非洲发病率较高。在沙特阿拉伯也很常见。在一组经组织学确诊的54例连续患者中，男女比例为10:1，是报道中最高的。发病高峰年龄在40至60岁之间，平均生存期为8个月。这与非洲的肝细胞癌不同，非洲患者年龄在25至35岁之间，病情进展迅速，类似脓肿。80%的病例经组织学诊断或临床提示为大结节性肝硬化。55%的患者血清HBsAg呈阳性，而健康献血者中这一比例为8%。这些数据与高发地区的报告同样重要，有力地表明乙肝病毒感染与原发性肝细胞癌的发生之间可能存在因果关系。
