Modrak J B, Langner R O
Atherosclerosis. 1980 Oct;37(2):211-8. doi: 10.1016/0021-9150(80)90006-4.
Male adult New Zealand rabbits were fed a 2% cholesterol diet for 60 days followed by 10, 20, or 30 days of normal low cholesterol diet. Collagen synthesis was estimated by measuring aortic prolyl hydroxylase activity. Tissue cholesterol accumulation rates were estimated by dividing total tissue cholesterol by the number of experimental days. It was found there was a high degree of correlation between aortic collagen synthetic activity and the rate of aortic cholesterol accumulation. These data were interpreted as suggesting that increased collagen synthesis may be associated with the accumulation and/or retention of increased aortic cholesterol.
成年雄性新西兰兔被喂食含2%胆固醇的饮食60天，随后再喂食10、20或30天正常的低胆固醇饮食。通过测量主动脉脯氨酰羟化酶活性来估计胶原蛋白的合成。通过将总组织胆固醇除以实验天数来估计组织胆固醇积累率。结果发现，主动脉胶原蛋白合成活性与主动脉胆固醇积累率之间存在高度相关性。这些数据被解释为表明胶原蛋白合成增加可能与主动脉胆固醇增加的积累和/或潴留有关。
