Langner R O, Modrak J B
Atherosclerosis. 1976 Jul-Aug;24(1-2):149-53. doi: 10.1016/0021-9150(76)90072-1.
Male adult New Zealand rabbits were fed a 2% cholesterol diet for 30 of 60 days in order to determine the effect of hypercholesterolemia on aortic collagen synthesis. Collagen synthetic activity was estimated by measuring tissue prolyl hydroxylase activity and the amount of tissue collagen was estimated by measuring tissue hydroxyproline levels. Following 30 or 60 days of feeding there was a significant increase in both tissue and serum cholesterol indicating the onset of hypercholesterolemia. Measurement of collagen synthetic activity and tissue collagen levels demonstrated no increase over control tissues. These data therefore indicate that hypercholesterolemia is not a direct stimulus of tissue collagen synthetic activity.
雄性成年新西兰兔在60天中的30天被喂食含2%胆固醇的饮食，以确定高胆固醇血症对主动脉胶原合成的影响。通过测量组织脯氨酰羟化酶活性来估计胶原合成活性，并通过测量组织羟脯氨酸水平来估计组织胶原含量。喂食30天或60天后，组织和血清胆固醇均显著升高，表明高胆固醇血症开始。胶原合成活性和组织胶原水平的测量结果显示，与对照组织相比没有增加。因此，这些数据表明高胆固醇血症不是组织胶原合成活性的直接刺激因素。
