皮肤继发性黑色素瘤的胶原酶免疫定位研究
Collagenase immunolocalization studies of cutaneous secondary melanomas.
作者信息
Woolley D E, Grafton C A
出版信息
Br J Cancer. 1980 Aug;42(2):260-5. doi: 10.1038/bjc.1980.225.
Abstract
Immunoreactive collagenase has been demonstrated in 5/14 specimens of cutaneous secondary melanomas. In contrast, very little enzyme was seen in 10 specimens of normal human skin. All specimens were fixed within minutes of excision. These findings support the hypothesis that collagenase facilitates connective-tissue breakdown which is associated with tumour invasiveness and metastatic spread.
摘要
免疫反应性胶原酶已在14例皮肤继发性黑色素瘤标本中的5例中得到证实。相比之下，在10例正常人皮肤标本中仅见极少量的该酶。所有标本均在切除后数分钟内固定。这些发现支持了胶原酶促进与肿瘤侵袭和转移扩散相关的结缔组织分解这一假说。
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