小鼠品系对无毒力的Semliki森林病毒感染所致脑炎和脱髓鞘发病机制的影响。
The effect of mouse strain on the pathogenesis of the encephalitis and demyelination induced by avirulent Semliki Forest virus infections.
作者信息
Suckling A J, Jagelman S, Illavia S J, Webb H E
出版信息
Br J Exp Pathol. 1980 Jun;61(3):281-4.
Abstract
Mice from the following strains--Simpson, SWR/J, TO, CBA/Ca, CW (outbred), LAC/G (outbred), SJL/J and Swiss A2G (outbred)--were infected i.p. with avirulent Semliki Forest virus. Clinical signs of disease were noted, histopathological changes assessed and the blood and brain virus infectivities and serum immunoglobulin levels were measured. Only the CW, TO and Swiss/A2G animals showed convincing evidence of demyelination at the light microscopy level but all strains developed encephalitis and microcystic (spongiform) lesions.
摘要
以下品系的小鼠——辛普森、SWR/J、TO、CBA/Ca、CW（远交群）、LAC/G（远交群）、SJL/J和瑞士A2G（远交群）——经腹腔注射无毒力的Semliki森林病毒。记录疾病的临床症状，评估组织病理学变化，并测量血液和脑内的病毒感染性以及血清免疫球蛋白水平。只有CW、TO和瑞士/A2G品系的动物在光学显微镜水平上显示出令人信服的脱髓鞘证据，但所有品系均出现了脑炎和微囊性（海绵状）病变。
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