小鼠品系对无毒力的Semliki森林病毒感染所致脑炎和脱髓鞘发病机制的影响。
The effect of mouse strain on the pathogenesis of the encephalitis and demyelination induced by avirulent Semliki Forest virus infections.
作者信息
Suckling A J, Jagelman S, Illavia S J, Webb H E
出版信息
Br J Exp Pathol. 1980 Jun;61(3):281-4.
Abstract
Mice from the following strains--Simpson, SWR/J, TO, CBA/Ca, CW (outbred), LAC/G (outbred), SJL/J and Swiss A2G (outbred)--were infected i.p. with avirulent Semliki Forest virus. Clinical signs of disease were noted, histopathological changes assessed and the blood and brain virus infectivities and serum immunoglobulin levels were measured. Only the CW, TO and Swiss/A2G animals showed convincing evidence of demyelination at the light microscopy level but all strains developed encephalitis and microcystic (spongiform) lesions.
摘要
以下品系的小鼠——辛普森、SWR/J、TO、CBA/Ca、CW（远交群）、LAC/G（远交群）、SJL/J和瑞士A2G（远交群）——经腹腔注射无毒力的Semliki森林病毒。记录疾病的临床症状，评估组织病理学变化，并测量血液和脑内的病毒感染性以及血清免疫球蛋白水平。只有CW、TO和瑞士/A2G品系的动物在光学显微镜水平上显示出令人信服的脱髓鞘证据，但所有品系均出现了脑炎和微囊性（海绵状）病变。
相似文献
1
2
Virus-associated demyelination. A model using avirulent Semliki Forest virus infection of mice.
J Neurol Sci. 1978 Nov;39(1):147-54. doi: 10.1016/0022-510x(78)90195-8.
3
Semliki Forest virus-induced, immune-mediated demyelination: adoptive transfer studies and viral persistence in nude mice.塞姆利基森林病毒诱导的免疫介导脱髓鞘：裸鼠中的过继转移研究及病毒持续性
J Gen Virol. 1987 Feb;68 ( Pt 2):377-85. doi: 10.1099/0022-1317-68-2-377.
4
Demyelination induced in mice by avirulent Semliki Forest virus. I. Virology and effects on optic nerve.
Neuropathol Appl Neurobiol. 1982 Jan-Feb;8(1):35-42. doi: 10.1111/j.1365-2990.1982.tb00255.x.
5
Properties of host and virus which influence defective interfering virus mediated-protection of mice against Semliki Forest virus lethal encephalitis. Brief report.
Arch Virol. 1984;81(1-2):185-8. doi: 10.1007/BF01309308.
6
Evidence for a T-cell related factor as the cause of demyelination in mice following Semliki Forest virus infection.
Brain Res. 1988 Aug 30;459(1):145-7. doi: 10.1016/0006-8993(88)90294-6.
7
8
Blood brain barrier disturbance and immunoglobulin G levels in the cerebrospinal fluid of the mouse following peripheral infection with the demyelinating strain of Semliki Forest virus.
J Neurol Sci. 1982 Dec;57(2-3):307-18. doi: 10.1016/0022-510x(82)90037-5.
9
Semliki Forest virus (A7[74]) infection of adult mice induces an immune-mediated demyelinating encephalomyelitis.
Ann N Y Acad Sci. 1988;540:672-3. doi: 10.1111/j.1749-6632.1988.tb27208.x.
10
Semliki Forest virus induced, immune mediated demyelination: the effect of irradiation.塞姆利基森林病毒诱导的免疫介导性脱髓鞘：辐射的影响
Br J Exp Pathol. 1987 Feb;68(1):101-13.
引用本文的文献
1
Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures.旧大陆甲病毒的神经发病机制：医学应对措施研发的考量因素
Viruses. 2025 Feb 14;17(2):261. doi: 10.3390/v17020261.
2
Viral mouse models used to study multiple sclerosis: past and present.用于研究多发性硬化症的病毒小鼠模型：过去和现在。
Arch Virol. 2021 Apr;166(4):1015-1033. doi: 10.1007/s00705-021-04968-5. Epub 2021 Feb 13.
3
Pathogenesis of virus-induced demyelination.病毒诱导的脱髓鞘病变的发病机制。
Adv Virus Res. 1993;42:249-324. doi: 10.1016/s0065-3527(08)60087-1.
4
Borna disease virus in mice: host-specific differences in disease expression.小鼠中的博尔纳病病毒：疾病表现的宿主特异性差异。
J Virol. 1993 Jan;67(1):548-52. doi: 10.1128/JVI.67.1.548-552.1993.
5
Oligodendrocyte infection and demyelination produced in mice by the M9 mutant of Semliki Forest virus.由塞姆利基森林病毒M9突变体在小鼠中引发的少突胶质细胞感染和脱髓鞘病变。
Acta Neuropathol. 1983;60(3-4):257-65. doi: 10.1007/BF00691874.
本文引用的文献
1
THE IMMUNOGLOBULINS OF MICE. 4. SERUM IMMUNOGLOBULIN CHANGES FOLLOWING BIRTH.小鼠的免疫球蛋白。4. 出生后血清免疫球蛋白的变化
Proc Soc Exp Biol Med. 1965 Mar;118:596-600. doi: 10.3181/00379727-118-29914.
2
A method for the combined staining of cells and fibers in the nervous system.一种用于神经系统中细胞和纤维联合染色的方法。
J Neuropathol Exp Neurol. 1953 Oct;12(4):400-3. doi: 10.1097/00005072-195312040-00008.
3
Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
4
The pathogenesis of avirulent Semliki Forest virus infections in athymic nude mice.
J Gen Virol. 1978 Dec;41(3):599-607. doi: 10.1099/0022-1317-41-3-599.
5
Histopathological and enzyme histochemical changes in experimental Semliki Forest virus infection in mice and their relevance to scrapie.
J Comp Pathol. 1978 Jul;88(3):335-44. doi: 10.1016/0021-9975(78)90038-5.
Zotero 插件