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与无MTV的小鼠相比,感染MTV的C3H小鼠对肝癌22A细胞的免疫反应性增强

[Increased immunologic reactivity against hepatoma 22A cells in MTV-infected C3H mice in comparison to MTV-free mice].

作者信息

Lavrovskiĭ V A, Viksler V Kh

出版信息

Biull Eksp Biol Med. 1980 Oct;90(10):467-9.

PMID:6252986
Abstract

Some tumors of no mammary tissue origin (sarcoma, hepatoma) grew more effectively in MTV-free mice (C3Hf) as compared with MTV-infected mice (C3H/He), whereas the tumors of mammary gland origin grew more rapidly in the latter ones. It has been shown that C3H/He mice develop a stronger specific immune reaction against hepatoma 22a cells than do C3H/f mice and that the animals of MTV-bearing subline exhibit a higher natural killer activity against these cells.

摘要

一些非乳腺组织起源的肿瘤(肉瘤、肝癌)在无MTV的小鼠(C3Hf)中比在感染MTV的小鼠(C3H/He)中生长得更有效,而乳腺组织起源的肿瘤在后者中生长得更快。已经表明,C3H/He小鼠对肝癌22a细胞产生的特异性免疫反应比C3H/f小鼠更强,并且携带MTV的亚系动物对这些细胞表现出更高的自然杀伤活性。

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