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与未感染MTV的C3H小鼠相比,感染MTV的小鼠对肝癌22a细胞的免疫反应增强。

Enhanced immune reactivity to hepatoma 22a cells in MTV-infected compared with MTV-free C3H mice.

作者信息

Lavrovsky V A, Viksler V K

出版信息

Immunology. 1981 Dec;44(4):671-6.

Abstract

The transplantability and growth rate of mouse mammary and non-mammary tumours (sarcoma and hepatoma) were compared in MTV-free (MTV-) and MTV-infected (MTV+) C3H mice. It was demonstrated that sarcoma and hepatoma, in contrast to mammary tumours, grew better in MTV- mice. The difference between C3H sublines in the growth of hepatoma transplants was found to be determined by the stronger specific immune response and higher natural lymph node cell cytotoxicity in MTV+ mice.

摘要

在无小鼠乳腺肿瘤病毒(MTV-)和感染小鼠乳腺肿瘤病毒(MTV+)的C3H小鼠中,比较了小鼠乳腺肿瘤和非乳腺肿瘤(肉瘤和肝癌)的移植性和生长速率。结果表明,与乳腺肿瘤不同,肉瘤和肝癌在MTV-小鼠中生长得更好。发现MTV+小鼠中肝癌移植生长的C3H亚系差异是由更强的特异性免疫反应和更高的天然淋巴结细胞细胞毒性决定的。

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