Korotkina R N, Nosova I M, Zaĭdenberg M A, Karelin A A
Biull Eksp Biol Med. 1980 Sep;90(9):361-3.
The effect of intraperitoneal administration of cGMP (0.5 mg per animal) on carbohydrate metabolism of wound area muscle tissue was studied in experiments on rats with linear skin wounds. The content of glycogen, gluconeogenesis, activity of glycogen phosphorylase, lactate dehydrogenase and malate dehydrogenase were studied. Cyclic GMP induced a substantial activation of glycogen metabolism (elevation of gluconeogenesis, increase in the activity of glycogen phosphorylase) even the third day after the operation. The animals not given cGMP demonstrated such an activation only the fifth day following the operation. Under the effect of cGMP the activity of lactate dehydrogenase rose the third day after the operation. Thus cGMP administration to the animals with wounds leads to an earlier mobilization of energy resources thereby promoting the acceleration of wound healing.
在患有线性皮肤伤口的大鼠实验中，研究了腹腔注射cGMP（每只动物0.5毫克）对伤口部位肌肉组织碳水化合物代谢的影响。研究了糖原含量、糖异生作用、糖原磷酸化酶、乳酸脱氢酶和苹果酸脱氢酶的活性。即使在手术后第三天，环鸟苷酸也能显著激活糖原代谢（糖异生作用增强，糖原磷酸化酶活性增加）。未给予cGMP的动物仅在手术后第五天出现这种激活。在cGMP的作用下，乳酸脱氢酶的活性在手术后第三天升高。因此，给受伤动物施用cGMP可导致更早地动员能量资源，从而促进伤口愈合加速。
