Nosova I M, Zaĭdenberg M A, Petrosova V N, Seĭfulla R D, Karelin A A
Biull Eksp Biol Med. 1979 Jun;87(6):591-4.
Changes in the content of cyclic nucleotides (cAMP and cGMP) in the wound tissues (muscles and granulations) were studied in experiments on rats. A wound with skin defect in the dorsal area with a crushed underlying muscle served as an experimental model. It was shown that the cAMP content in the muscular tissue rises twice: during the 1st day and to a greater measure on the 7th day. The cGMP content slightly increases on the 1-4th day, drops on the 7th day and increases cAMP concentration changes similarly to that inthe muscular tissue: it increases on the 7th day and drops on the 14th day. On the contrary, the cGMP content curve in granulations is more monotonous, only a slight increase being observed on the 7th day.
在大鼠实验中研究了伤口组织（肌肉和肉芽）中环核苷酸（cAMP和cGMP）含量的变化。以背部区域有皮肤缺损且下方肌肉受压的伤口作为实验模型。结果表明，肌肉组织中的cAMP含量升高了两倍：在第1天升高，在第7天升高幅度更大。cGMP含量在第1至4天略有增加，在第7天下降，其浓度变化与肌肉组织中的情况类似：在第7天升高，在第14天下降。相反，肉芽中cGMP含量曲线较为平缓，仅在第7天观察到略有增加。
