激肽与血管紧张素。人肺动脉和肺静脉培养的内皮细胞中的血管紧张素I转换酶（激肽酶II）。

Kinins and angiotensins. Angiotensin I converting enzyme (kininase II) in endothelial cells cultured from human pulmonary arteries and veins.

作者信息

Johnson A R, Schulz W W, Noguiera L A, Erdös E G

出版信息

Clin Exp Hypertens (1978). 1980;2(3-4):659-74. doi: 10.3109/10641968009037135.

DOI:10.3109/10641968009037135

Abstract

Human pulmonary endothelial cells were used to study the metabolism of angiotensin I and bradykinin by angiotensin I converting enzyme (kininase II; ACE). The endothelial cells cultured from pulmonary arteries and veins differed with respect to their enzyme activity and their surface structure, as viewed with scanning electron microscopy. Cells from adult pulmonary arteries had greater ACE activity than cells from either adult pulmonary veins or fetal pulmonary arteries. In addition, cells from adult pulmonary arteries exhibited more prominent surface projections than cells from veins or fetal pulmonary arteries. A brief exposure to trypsin decreased the ACE activity in cells from arteries but not in cells from veins. Possible the differences in ACE activity between these cells are related to their surface structures.

摘要

用人肺内皮细胞研究血管紧张素I转换酶（激肽酶II；ACE）对血管紧张素I和缓激肽的代谢。从肺动脉和肺静脉培养的内皮细胞，在酶活性和表面结构方面有所不同，这是通过扫描电子显微镜观察到的。来自成人肺动脉的细胞比来自成人肺静脉或胎儿肺动脉的细胞具有更高的ACE活性。此外，来自成人肺动脉的细胞比来自肺静脉或胎儿肺动脉的细胞表现出更突出的表面突起。短暂暴露于胰蛋白酶会降低动脉来源细胞中的ACE活性，但不会降低静脉来源细胞中的ACE活性。这些细胞之间ACE活性的差异可能与其表面结构有关。