Anjaneyulu K, Anjaneyulu R, Malaisse W J
J Inorg Biochem. 1980 Oct;13(2):179-88. doi: 10.1016/s0162-0134(00)80120-8.
Native ionophores extracted from isolated pancreatic islets were able to transport Ca2+ from one aqueous medium into another across an organic immiscible phase. In the presence of a K+, Na+, Li+, or H+ gradient, Ca2+ was transported against its own concentration gradient from the medium of low monovalent-cation concentration to the opposite medium. The transport of Ca2+ was abolished by the organic calcium-antagonist suloctidil. These findings provide a model for the process of Na-Ca countertransport in islet cells and its inhibition in response to the conversion of nutrient secretagogues to their acidic metabolites.
从分离的胰岛中提取的天然离子载体能够将钙离子从一种水相介质跨有机不混溶相转运到另一种水相介质中。在钾离子、钠离子、锂离子或氢离子梯度存在的情况下，钙离子逆着自身浓度梯度从单价阳离子浓度低的介质转运到相反的介质中。钙离子的转运被有机钙拮抗剂舒洛地尔所阻断。这些发现为胰岛细胞中钠钙逆向转运过程及其对营养促分泌剂转化为其酸性代谢产物的反应抑制提供了一个模型。
