Smith K J, Bostock H, Hall S M
J Neurol Sci. 1982 Apr;54(1):13-31. doi: 10.1016/0022-510x(82)90215-5.
The changing electrical and morphological properties of demyelinating and remyelinating nerve fibres have been studied in rat ventral roots after intrathecal injection of lysophosphatidyl choline (LPC). The spatial distribution of electrical excitability within the lesion has been studied in undissected single fibres using high-resolution longitudinal current analysis. The distribution of excitability has been correlated with the ultrastructure of the fibres and with the distribution of the surrounding Schwann cells. Demyelinated axolemma was initially not excited, but conduction across demyelinated internodes appeared progressively from the 4th day after LPC injection. Conduction was never continuous, but proceeded via new foci of inward membrane current as early as 4 days after LPC injection, i.e. 3 days before the onset of remyelination. It is suggested that these foci (termed phi-nodes to distinguish them from the nodes of Ranvier distributed along myelinated nerve fibres) are precursors of nodes of Ranvier, and may indicate aggregates of sodium channels which form along the demyelinated axolemma prior to remyelination.
鞘内注射溶血磷脂酰胆碱（LPC）后，研究了大鼠腹根中脱髓鞘和再髓鞘化神经纤维电特性和形态特性的变化。利用高分辨率纵向电流分析，在未解剖的单纤维中研究了损伤部位内电兴奋性的空间分布。兴奋性分布与纤维的超微结构以及周围施万细胞的分布相关。脱髓鞘的轴膜最初不兴奋，但从LPC注射后第4天开始，脱髓鞘节段间的传导逐渐出现。传导从未连续，但早在LPC注射后4天，即再髓鞘化开始前3天，就通过新的内向膜电流灶进行。有人认为，这些病灶（称为φ结，以区别于沿有髓神经纤维分布的郎飞结）是郎飞结的前体，可能表明在再髓鞘化之前沿脱髓鞘轴膜形成的钠通道聚集体。
