Yasuda K, Nozawa G, Goto T, Sasaki N, Ishizu S
J Toxicol Sci. 1980 Feb;5(1):11-21. doi: 10.2131/jts.5.11.
Allergic contact dermatitis occurred with 2, 4-toluene diisocyanate (TDI) in BALB/c mice. The results were obtained by the measurement of the ear thickness after challenged to the ear with 1% TDI in olive oil in mice previously sensitized with 5% TDI. The ear swelling rate at 48 hr postchallenge in sensitized mice was more than twice of that in unsensitized mice. In BALB/c-nu/nu (nude) mice, delayed type hypersensitivity could not be induced even when a 30% TDI solution was applied. These results suggest that T cells may play an essential role in contact sensitivity to TDI in BALB/c mice.
在BALB/c小鼠中，2,4-甲苯二异氰酸酯（TDI）引发了过敏性接触性皮炎。通过测量先前用5% TDI致敏的小鼠在用1% TDI橄榄油溶液刺激耳部后的耳厚度得出结果。致敏小鼠在激发后48小时的耳肿胀率是未致敏小鼠的两倍多。在BALB/c-nu/nu（裸）小鼠中，即使应用30%的TDI溶液也无法诱导迟发型超敏反应。这些结果表明，T细胞可能在BALB/c小鼠对TDI的接触敏感性中起重要作用。
