Kudriashov B A, Shapiro F B, Ul'ianov A M
Probl Endokrinol (Mosk). 1980 Sep-Oct;26(5):59-63.
Intensity of heparin (H) clearance is reduced and the latter gets retained in the blood flow in rats subjected to immobilization stress. A stable fall is seen when immobilization is continued not less than 20 minutes. A decrease in the rate of H secretion from the blood flow is associated with ACTH concentration in the blood. Immobilization stress does not affect the intensity of H clearance in the animals with ACTH-release blocked by DOCA administration. ACTH use was conducive to a further decrease in H clearance intensity in animals exposed to immobilization. The rate of H secretion from the blood flow in this case is minimum and significantly differs from the rate of H clearance in animals immobilized without ACTH administration.
在遭受固定应激的大鼠中，肝素（H）清除强度降低，且肝素会滞留在血流中。当固定持续不少于20分钟时，可观察到肝素清除强度持续下降。肝素从血流中分泌速率的降低与血液中促肾上腺皮质激素（ACTH）的浓度有关。通过给予醋酸脱氧皮质酮（DOCA）阻断促肾上腺皮质激素释放后，固定应激并不影响动物体内肝素的清除强度。使用促肾上腺皮质激素会导致遭受固定应激动物的肝素清除强度进一步降低。在这种情况下，肝素从血流中的分泌速率最低，且与未给予促肾上腺皮质激素而遭受固定应激动物的肝素清除速率有显著差异。
