Landas S, Phillips M I, Stamler J F, Raizada M K
Science. 1980 Nov 14;210(4471):791-3. doi: 10.1126/science.6254147.
The organum vasculosum of the lamina terminalis has been implicated as the site of receptors mediating central responses of angiotensin II. Up to now, this had been based on indirect evidence, but direct visualization of angiotensin II at its site of action has now been achieved by the use of a biologically active fluorescent angiotensin II agonist. The ventricular surface of the organum vasculosum lamina terminalis showed intense fluorescence, which was virtually eliminated by an excess of unlabeled angiotensin II.
终板血管器被认为是介导血管紧张素II中枢反应的受体所在部位。到目前为止，这一直是基于间接证据，但现在通过使用具有生物活性的荧光血管紧张素II激动剂，已在其作用部位直接观察到血管紧张素II。终板血管器的脑室表面呈现强烈荧光，而过量的未标记血管紧张素II几乎可将其消除。
