Czyba J C
Sem Hop. 1980 Oct 15;56(37-38):1483-5.
Administration of 2 mg/kg/day of veralipride to intact female rats for 3 weeks provokes mammary gland development and, in some animals, the onset of secretory activity. These modifications do not appear after veralipride administration, under the same conditions, to castrated female rats. In castrated female rats previously conditioned by estradiol benzoate administration, some development of several acinous islets is observed in about half of the animals treated or not with veralipride. This suggests the development of a sensitivity of the mammary gland to the action of pituitary hormones, the secretion of which is stimulated by either castration or veralipride. It would seem that the absence of corpora lutea secretions prevented as great a mammary gland development as that observed in intact animals treated with veralipride.
给完整的雌性大鼠每日注射2毫克/千克的维拉必利，持续3周，会引发乳腺发育，在一些动物中还会引发分泌活动。在相同条件下，给阉割后的雌性大鼠注射维拉必利后，并未出现这些变化。在先前经苯甲酸雌二醇处理过的阉割雌性大鼠中，大约一半接受或未接受维拉必利治疗的动物，其多个腺泡胰岛出现了一些发育。这表明乳腺对垂体激素的作用产生了敏感性，垂体激素的分泌受到阉割或维拉必利的刺激。似乎黄体分泌的缺失阻止了乳腺像在用维拉必利治疗的完整动物中观察到的那样大幅发育。
