Tahiri-Zagret C, Oria A
Ann Endocrinol (Paris). 1979;40(2):129-35.
Sulpiride or Dogmatil (Delagrange, Paris) was injected to male rats at the rate of 40 mg/day for either 10 or 20 days. Ponderal fluctuations of the accessory organs followed by a quantitative analysis of fructose and of serum acid phosphatases issued from testis epididymis and prostates (PAP) were studied. The coagulating glands alone reacted strongly and their initial weight doubled in 20 days. On the contrary, the fructose decreased sharply in all accessory glands especially in the coagulating glands. The PAP decreased slightly. The fact the concentration of serum PAP remained relatively high even in the castrated males, can be explained by the increase in the lysosomial activity due to retention and diminution of secretion granules. Fructose and PAP are conditioned by androgens and their quantitative decrease suggests that the testosterone level decreased. Hyperprolactinemia induced by Sulpiride is concomittent to testosterone diminution and the effect of each hormone cannot easily be separated. In the castrated animals the effects of Sulpiride were minimized due to the difficulty in observing significant variations between treated and untreated castrates.
将舒必利或多马替（德拉格朗日公司，巴黎）以每天40毫克的剂量注射给雄性大鼠，持续10天或20天。研究了附属器官的体重波动情况，随后对睾丸、附睾和前列腺产生的果糖及血清酸性磷酸酶（PAP）进行了定量分析。仅凝固腺反应强烈，其初始重量在20天内翻倍。相反，所有附属腺中的果糖含量急剧下降，尤其是凝固腺。PAP略有下降。即使在去势雄性大鼠中血清PAP浓度仍相对较高这一事实，可以通过由于分泌颗粒的潴留和减少导致溶酶体活性增加来解释。果糖和PAP受雄激素调节，它们的定量减少表明睾酮水平下降。舒必利诱导的高催乳素血症与睾酮减少同时出现，且每种激素的作用不易区分。在去势动物中，由于难以观察到治疗组和未治疗组去势大鼠之间的显著差异，舒必利的作用被最小化。
