[Morphological changes of guinea pig lungs after aerosol application of lipiodol ultrafluid (author's transl)].

The morphological lung changes of guinea pigs, exposed about 10 days to an aerosol of lipiodol ultrafluid were investigated with light microscopy and enzyme histochemistry 3, 10, 18, 25, 32, 38 and 46 days later. There was a prominent diffuse ore focal thickening of alveolar septa by accumulations of macrophages. Important are changes on the vascular endothelium of muscular pulmonary arteries with swollen and vacuolised endothelial cells. Around pulmonary veins accumulations of lymphocytes were detected. With histochemistry slight increase of phospholipids in alveolar epithelial cells was observed predominantly in the first three days after aerosol application. The intensity of the morphological changes showed a time dependent biphasic cycle with peaks of maximum at the 10th and 38th day after applicationof aerosol.