Eckert H, Kandt D
Z Erkr Atmungsorgane. 1975 Jan;142(1):59-67.
The morphological changes were investigated by male rats after aerosol application of mineral oil above a period of three weeks. Beginning in the second week, there was a permanent increase of macrophages and foam cells in the alveolar septa and alveolar lumina in closed relation to the deposited mineral oil, visible by dark field illumination. The macrophages and foam cells showed a high activity of non-specific esterasis and acid phosphatasis whereas the activity of adenosine triphosphatasis clear decreased. In the third week the formation of focal granulomas started predominantly existing of histiocytes and only few foam cells.
通过对雄性大鼠进行为期三周以上的矿物油气溶胶吸入，研究其形态学变化。从第二周开始，肺泡隔和肺泡腔内的巨噬细胞和泡沫细胞持续增加，与沉积的矿物油密切相关，在暗视野照明下可见。巨噬细胞和泡沫细胞显示出高活性的非特异性酯酶和酸性磷酸酶，而三磷酸腺苷酶的活性明显降低。在第三周，开始形成局灶性肉芽肿，主要由组织细胞组成，只有少数泡沫细胞。
