The 5'-monophosphates of 5-propyl- and 5-ethyl-2'-deoxyuridine do not inhibit the replication of deoxythymidine kinase deficient (TK-) mutants of herpes simplex virus. - Suppr | 超能文献

The 5'-monophosphates of 5-propyl- and 5-ethyl-2'-deoxyuridine do not inhibit the replication of deoxythymidine kinase deficient (TK-) mutants of herpes simplex virus.

作者信息

De Clercq E, Kulikowski T, Shugar D

出版信息

Biochem Pharmacol. 1980 Oct 15;29(20):2883-5. doi: 10.1016/0006-2952(80)90028-3.

DOI:10.1016/0006-2952(80)90028-3

Abstract

摘要

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The 5'-monophosphates of 5-propyl- and 5-ethyl-2'-deoxyuridine do not inhibit the replication of deoxythymidine kinase deficient (TK-) mutants of herpes simplex virus.

Biochem Pharmacol. 1980 Oct 15;29(20):2883-5. doi: 10.1016/0006-2952(80)90028-3.

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Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷表现出2型单纯疱疹病毒敏感性的1型单纯疱疹病毒。

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Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.用1型单纯疱疹病毒胸苷激酶基因转化的小鼠乳腺FM3A癌细胞对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物的生长抑制特性高度敏感。

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Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物对单纯疱疹病毒1型胸苷激酶基因转化的小鼠乳腺FM3A癌细胞增殖的选择性抑制作用

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Selection of L cell sublines resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine.对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷具有抗性的L细胞亚系的选择。

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Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷（BVDU）及相关化合物对单纯疱疹病毒（HSV）感染细胞和HSV胸苷激酶基因转化细胞的抑制作用。

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The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.

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Virus-drug resistance: thymidine kinase-deficient (TK-) mutants of herpes simplex virus. Therapeutic approaches.病毒耐药性：单纯疱疹病毒胸苷激酶缺陷（TK-）突变体。治疗方法。

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Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.

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Virus drug-resistance: mechanisms and consequences.病毒耐药性：机制与后果

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Combined interaction of antiherpes substances and interferon beta on the multiplication of herpes simplex virus.抗疱疹物质与β干扰素对单纯疱疹病毒增殖的联合相互作用

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