中枢α-肾上腺素能受体系统参与促甲状腺激素释放激素诱导的体温过高的抗抑郁药增强作用。
Involvement of a central alpha-adrenoceptor system in antidepressant potentiation of hyperthermia induced by thyrotropin releasing hormone.
作者信息
Desiles M, Puech A J, Rips R
出版信息
Br J Pharmacol. 1980 Jun;69(2):163-6. doi: 10.1111/j.1476-5381.1980.tb07885.x.
Abstract
Thyrotropin releasing hormone (TRH) causes hyperthermia in mice which is potentiated by tricyclic antidepressants (nortriptyline, imipramine, clomipramine, amitriptyline), the monoamine oxidase inhibitor, tranylcypromine, and various other antidepressants (maprotiline, nomifensin, viloxazine). Only iprindole is ineffective. The effect of mianserin, itself hypothermic, could not be interpreted. A property shared by the potentiating substances seems to be activation of a central adrenoceptor system. The potentiation of TRH-induced hyperthermia which seems to be specific to antidepressants might be used in the selection of antidepressants.
摘要
促甲状腺激素释放激素（TRH）可使小鼠体温升高，三环类抗抑郁药（去甲替林、丙咪嗪、氯米帕明、阿米替林）、单胺氧化酶抑制剂反苯环丙胺以及其他各种抗抑郁药（马普替林、诺米芬辛、维洛沙嗪）可增强这一作用。只有茚满二氮卓无效。米安色林本身可降低体温，其作用无法解释。增强作用物质共有的一个特性似乎是激活中枢肾上腺素能受体系统。TRH诱导的体温升高的增强作用似乎是抗抑郁药所特有的，可用于抗抑郁药的筛选。
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Involvement of a central alpha-adrenoceptor system in antidepressant potentiation of hyperthermia induced by thyrotropin releasing hormone.中枢α-肾上腺素能受体系统参与促甲状腺激素释放激素诱导的体温过高的抗抑郁药增强作用。
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引用本文的文献
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The effect of highly selective inhibitors of the uptake of noradrenaline or 5-hydroxytryptamine on TRH-induced hyperthermia in mice.去甲肾上腺素或5-羟色胺摄取的高选择性抑制剂对促甲状腺激素释放激素诱导的小鼠体温过高的影响。
Psychopharmacology (Berl). 1983;81(1):48-53. doi: 10.1007/BF00439273.
2
Use of potentiation of thyrotrophin releasing hormone (TRH)-induced hyperthermia as a test for screening antidepressants which activate alpha-adrenoceptor systems.使用促甲状腺素释放激素（TRH）诱导的体温过高增强作用作为筛选激活α-肾上腺素能受体系统的抗抑郁药的测试。
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3
Potentiation by TRH of the effect of imipramine on the forced-swimming test.促甲状腺激素释放激素对丙咪嗪在强迫游泳试验中作用的增强效应。
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本文引用的文献
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Blockade of noradrenaline uptake by 34276-Ba, a new antidepressant drug.新型抗抑郁药34276-Ba对去甲肾上腺素摄取的阻断作用。
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TRH potentiates behavioural changes following increased brain 5-hydroxytryptamine accumulation in rats.促甲状腺激素释放激素增强大鼠脑内5-羟色胺积累后行为的变化。
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Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone.促甲状腺激素释放激素对脑内去甲肾上腺素周转的增强作用。
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Evaluation of thyrotropin-releasing hormone as a potential antidepressant agent in the conscious dog.促甲状腺激素释放激素作为清醒犬潜在抗抑郁药的评估。
Life Sci. 1973 Dec 16;13(12):1789-97. doi: 10.1016/0024-3205(73)90126-4.
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Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum.诺米芬辛：一种新型强效大鼠脑纹状体突触体对多巴胺摄取的抑制剂。
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The effect of nomifensine on the depletion of brain serotonin and catecholamines induced respectively by fenfluramine and 6-hydroxydopamine in rats.诺米芬辛对大鼠中分别由芬氟拉明和6-羟基多巴胺诱导的脑5-羟色胺和儿茶酚胺耗竭的影响。
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