Plotnikoff N P, Breese G R, Prange A J
Pharmacol Biochem Behav. 1975 Jul-Aug;3(4):665-70. doi: 10.1016/0091-3057(75)90189-6.
The present study in mice demonstrated the TRH when administered over 5 days remained active in the Everett Dopamine Potentiation Test. No evidence of tolerance was observed. In fact, an accumulative effect of TRH appeared to take place. Ablation of the adrenals, ovaries, testes, pineal, spleen, parathyroid, one kidney, or thymus did disrupt this behavioral potentiation of dopamine by TRH. TRH was found to potentiate the effects of imipramine. T3, T4, and TSH were found to be active in the DOPA potentiating test. No overt toxicity was observed between TRH and pargyline or between TRH and DOPA. Toxicity was seen only when all three agents were used together. TRH was found active in young and old mice. TRH was also found active in potentiating the central effects of serotonin. Biogenic amine brain levels in mice were not altered by TRH when administered for five days. Alpha-methyl-p-tyrosine reduced the activity of TRH in the dopamine potentiation test, suggesting dopaminergic mechanisms are involved by a direct receptor interaction.
本项针对小鼠的研究表明，在埃弗雷特多巴胺增强试验中，连续5天给予促甲状腺激素释放激素（TRH）仍具有活性。未观察到耐受性证据。事实上，TRH似乎出现了累积效应。切除肾上腺、卵巢、睾丸、松果体、脾脏、甲状旁腺、一侧肾脏或胸腺确实会破坏TRH对多巴胺的这种行为增强作用。发现TRH可增强丙咪嗪的作用。在多巴增强试验中发现三碘甲状腺原氨酸（T3）、甲状腺素（T4）和促甲状腺激素（TSH）具有活性。在TRH与帕吉林之间或TRH与多巴之间未观察到明显毒性。仅当三种药物一起使用时才出现毒性。发现TRH在幼鼠和老年小鼠中均具有活性。还发现TRH在增强5-羟色胺的中枢作用方面具有活性。连续5天给予TRH不会改变小鼠脑中生物胺的水平。α-甲基对酪氨酸在多巴胺增强试验中降低了TRH的活性，表明多巴胺能机制通过直接受体相互作用参与其中。
