急性和慢性给予乙醇及其戒断对大鼠脑内γ-氨基丁酸受体结合的影响。
The effects of acute and chronic ethanol administration and its withdrawal on gamma-aminobutyric acid receptor binding in rat brain.
作者信息
Ticku M K
出版信息
Br J Pharmacol. 1980 Nov;70(3):403-10. doi: 10.1111/j.1476-5381.1980.tb08716.x.
Abstract
1 The effects of acute and chronic ethanol administration, and withdrawal on the binding of the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), was investigated in rat brain. 2 Acute ethanol (2 to 4 g/kg i.p. 30 min before removal of brain) produced an increase in the binding capacity of the low affinity GABA receptor binding site. 3 Following chronic ethanol administration (1 to 21 days), the GABA receptor binding characteristics were not altered. These results suggest a possible adaptation of GABA receptors to the continuous presence of ethanol at the GABA synapse. 4 During ethanol withdrawal, the affinity of the low affinity GABA receptor binding site was significantly lower than pair-fed controls at 8 and 16 h withdrawal. 5 These results suggest that GABA receptor sensitivity may play a role in some of the neuropharmacological effects of ethanol and in its withdrawal symptoms.
摘要
- 研究了急性和慢性给予乙醇以及戒断对大鼠脑中抑制性神经递质γ-氨基丁酸（GABA）结合的影响。2. 急性给予乙醇（在取脑前30分钟腹腔注射2至4克/千克）使低亲和力GABA受体结合位点的结合能力增加。3. 慢性给予乙醇（1至21天）后，GABA受体结合特性未改变。这些结果表明GABA受体可能对GABA突触处持续存在的乙醇产生适应性变化。4. 在乙醇戒断期间，低亲和力GABA受体结合位点的亲和力在戒断8小时和16小时时显著低于配对喂养的对照组。5. 这些结果表明，GABA受体敏感性可能在乙醇的某些神经药理学作用及其戒断症状中起作用。
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