Waalkes T P, Abeloff M D, Woo K B, Ettinger D S, Ruddon R W, Aldenderfer P
Cancer Res. 1980 Dec;40(12):4420-7.
Carcinoembryonic antigen (CEA) was measured at specific intervals in the plasma of 56 patients with small cell carcinoma of the lung. Of these patients, 47 had serial analyses for varying periods during their illness, 42 had pretreatment CEA levels, and 17 of the latter patients had determinations throughout the entire course of their disease. Pretreatment CEA levels were elevated above 2.5 ng/ml for 74% of the 42 patients and above 5.0 ng/ml for 48%. Although exceptions were noted, in general, a direct relationship was found between pretreatment CEA levels and extent of disease or tumor burden. Initial stage of disease, however, was more predictive of survival than was the pretreatment CEA level. With response to therapy, a corresponding decrease in CEA levels occurred for patients with an elevated pretreatment level. For those patients with a pretreatment CEA level below 5.0 ng/ml, an immediate slight increase in level was often seen associated with response and followed by a subsequent fall after one month. A rising CEA level was usually found with recurrence or progression of disease after initial response and occurred frequently prior to clinical evidence of progression. In combination with careful clinical evaluation, serial CEA measurements can aid in assessing tumor changes associated with treatment in patients with small cell carcinoma of the lung particularly at the times of recurrence or disease progression following a partial or complete response.
在56例小细胞肺癌患者的血浆中，在特定时间间隔测量癌胚抗原（CEA）。这些患者中，47例在患病期间进行了不同时间段的系列分析，42例有治疗前CEA水平，其中17例患者在整个病程中都进行了测定。42例患者中，74%的患者治疗前CEA水平高于2.5 ng/ml，48%的患者高于5.0 ng/ml。虽然有例外情况，但总体而言，治疗前CEA水平与疾病范围或肿瘤负荷之间存在直接关系。然而，疾病的初始阶段比治疗前CEA水平更能预测生存。随着治疗反应，治疗前水平升高的患者CEA水平相应下降。对于那些治疗前CEA水平低于5.0 ng/ml的患者，通常在反应时会立即出现水平轻微升高，随后在一个月后下降。在初始反应后疾病复发或进展时，通常会发现CEA水平升高，且常在临床出现进展证据之前频繁发生。结合仔细的临床评估，系列CEA测量有助于评估小细胞肺癌患者与治疗相关的肿瘤变化，特别是在部分或完全缓解后的复发或疾病进展时。
