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[多瘤病毒感染的各类细胞中病毒抗原合成的比较诱导]

[Comparative induction of viral antigen synthesis in various types of cells infected by polyoma virus].

作者信息

de Micco C, Tripier M F, Beau N, Meyer G

出版信息

C R Seances Acad Sci D. 1980 Sep 22;291(3):333-6.

PMID:6254683
Abstract

Induction of synthesis of the viral antigens T and V during polyoma virus infection was studied in primary Mouse and Hamster kidney and brain cultures, as well as in various types of human cells. The results show that: (1) Despite a very low percentage of positive cells by immunofluorescence, Hamster brain cells produced more viral antigen than kidney cells, as opposed to what was found in Mouse brain cells. (2) Most human cells produced neither T nor V antigens. Conversely, a large number of brain cells synthesized the T antigen very early after infection.

摘要

在原代小鼠、仓鼠肾和脑培养物以及各种类型的人类细胞中,研究了多瘤病毒感染期间病毒抗原T和V合成的诱导情况。结果表明:(1)尽管通过免疫荧光检测到的阳性细胞百分比非常低,但与小鼠脑细胞的情况相反,仓鼠脑细胞产生的病毒抗原比肾细胞更多。(2)大多数人类细胞既不产生T抗原也不产生V抗原。相反,大量脑细胞在感染后很早便合成了T抗原。

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