Costa G, Frisina N, de Pasquale R
Clin Endocrinol (Oxf). 1980 Jul;13(1):1-7. doi: 10.1111/j.1365-2265.1980.tb01016.x.
Sulpiride induces an increase in plasma prolactin and a simultaneous increase of aldosterone release in man. In isolated and superfused bovine adrenal glands, prolactin does not increase aldosterone production even in high concentrations, whereas sulpiride induces a significant and long lasting increase in the production of this hormone and a concomitant increase in the tissue levels of cAMP. This suggests a direct effect on the biosynthesis of aldosterone.
舒必利可使人体血浆催乳素水平升高，同时醛固酮释放量增加。在离体灌注的牛肾上腺中，即使高浓度的催乳素也不会增加醛固酮的生成，而舒必利可使该激素的生成显著且持久地增加，并使组织中环磷酸腺苷（cAMP）水平随之升高。这表明舒必利对醛固酮的生物合成有直接作用。
