甲氧氯普胺对醛固酮分泌影响的体内和体外研究。

In vivo and in vitro studies on the effect of metoclopramide on aldosterone secretion.

作者信息

Edwards C R, Al-Dujaili E A, Boscaro M, Quyyumi S, Miall P A, Rees L H

出版信息

Clin Endocrinol (Oxf). 1980 Jul;13(1):45-50. doi: 10.1111/j.1365-2265.1980.tb01021.x.

DOI:10.1111/j.1365-2265.1980.tb01021.x

Abstract

Metoclopramide, a dopamine antagonist drug, elevated plasma aldosterone and prolactin levels without significantly affecting plasma renin activity, ACTH or potassium. Studies with isolated perfused rat zona glomerulosa cells showed that metoclopramide could directly stimulate aldosterone release and that this action was blocked by dopamine. These results suggest that dopamine may play an important inhibitory role in the control of aldosterone secretion.

摘要

甲氧氯普胺是一种多巴胺拮抗剂药物，可提高血浆醛固酮和催乳素水平，而对血浆肾素活性、促肾上腺皮质激素或钾没有显著影响。对离体灌注的大鼠肾小球带细胞进行的研究表明，甲氧氯普胺可直接刺激醛固酮释放，且该作用可被多巴胺阻断。这些结果表明，多巴胺可能在醛固酮分泌的控制中发挥重要的抑制作用。