金黄色葡萄球菌中耐甲氧西林决定因素的遗传行为
Genetic behavior of the methicillin resistance determinant in Staphylococcus aureus.
作者信息
Stewart G C, Rosenblum E D
出版信息
J Bacteriol. 1980 Dec;144(3):1200-2. doi: 10.1128/jb.144.3.1200-1202.1980.
Abstract
The cotransformation frequency of mecC5 with pur-102 using Staphylococcus aureus C5 deoxyribonucleic acid was found to be approximately 45%. However, in cotransduction studies, there was a 15% cotransduction of purine prototrophy and methicillin sensitivity but, in the reciprocal cross, no purine-prototrophic plus Mecr cotransductants were obtained (frequency less than 0.06%). The data support the hypothesis that the mec determinant resides on an inserted deoxyribonucleic acid sequence in S. aureus and that there is no allelic equivalent in sensitive cells.
摘要
利用金黄色葡萄球菌C5的脱氧核糖核酸，发现mecC5与pur-102的共转化频率约为45%。然而，在共转导研究中，嘌呤原养型和甲氧西林敏感性的共转导率为15%，但在反向杂交中，未获得嘌呤原养型加Mecr共转导子（频率小于0.06%）。这些数据支持以下假设：mec决定簇位于金黄色葡萄球菌中插入的脱氧核糖核酸序列上，且敏感细胞中不存在等位基因等价物。
相似文献
1
Genetic behavior of the methicillin resistance determinant in Staphylococcus aureus.金黄色葡萄球菌中耐甲氧西林决定因素的遗传行为
J Bacteriol. 1980 Dec;144(3):1200-2. doi: 10.1128/jb.144.3.1200-1202.1980.
2
Chromosomal map location of the methicillin resistance determinant in Staphylococcus aureus.金黄色葡萄球菌中耐甲氧西林决定簇的染色体图谱定位。
J Bacteriol. 1978 Aug;135(2):460-5. doi: 10.1128/jb.135.2.460-465.1978.
3
Insertional inactivation of staphylococcal methicillin resistance by Tn551.Tn551对葡萄球菌耐甲氧西林的插入失活作用。
J Bacteriol. 1983 Apr;154(1):479-87. doi: 10.1128/jb.154.1.479-487.1983.
4
Identification of a Staphylococcus aureus transposon (Tn4291) that carries the methicillin resistance gene(s).携带耐甲氧西林基因的金黄色葡萄球菌转座子（Tn4291）的鉴定。
J Bacteriol. 1988 Jan;170(1):149-54. doi: 10.1128/jb.170.1.149-154.1988.
5
FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: molecular cloning and characterization.FemA，金黄色葡萄球菌中耐甲氧西林所必需的宿主介导因子：分子克隆与特性分析。
Mol Gen Genet. 1989 Oct;219(1-2):263-9. doi: 10.1007/BF00261186.
6
Transformation reveals a chromosomal locus of the gene(s) for methicillin resistance in Staphylococcus aureus.转化作用揭示了金黄色葡萄球菌中耐甲氧西林基因的染色体定位。
J Bacteriol. 1975 Sep;123(3):905-15. doi: 10.1128/jb.123.3.905-915.1975.
7
Genetics of methicillin resistance in Staphylococcus aureus.金黄色葡萄球菌耐甲氧西林的遗传学
J Antimicrob Chemother. 1989 May;23(5):671-3. doi: 10.1093/jac/23.5.671.
8
Modulation of protein A formation in Staphylococcus aureus by genetic determinants for methicillin resistance.耐甲氧西林金黄色葡萄球菌的遗传决定因素对蛋白A形成的调控
J Bacteriol. 1979 Dec;140(3):1028-35. doi: 10.1128/jb.140.3.1028-1035.1979.
9
Increase in transduction efficiency of Tn551 mediated by the methicillin resistance marker.由甲氧西林抗性标记介导的Tn551转导效率的提高。
J Bacteriol. 1983 Apr;154(1):533-5. doi: 10.1128/jb.154.1.533-535.1983.
10
New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity.金黄色葡萄球菌对甲氧西林耐药的新机制：缺乏PBP 2a基因且含有具有修饰青霉素结合能力的正常青霉素结合蛋白的临床分离株。
Antimicrob Agents Chemother. 1989 Nov;33(11):1869-74. doi: 10.1128/AAC.33.11.1869.
引用本文的文献
1
An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus.多种正、负因素相互作用调控金黄色葡萄球菌耐甲氧西林现象。
Microbiol Mol Biol Rev. 2022 Jun 15;86(2):e0015921. doi: 10.1128/mmbr.00159-21. Epub 2022 Apr 14.
2
Theaflavin-3,3´-digallate increases the antibacterial activity of β-lactam antibiotics by inhibiting metallo-β-lactamase activity.茶黄素-3,3´-二没食子酸酯通过抑制金属β-内酰胺酶活性增强β-内酰胺类抗生素的抗菌活性。
J Cell Mol Med. 2019 Oct;23(10):6955-6964. doi: 10.1111/jcmm.14580. Epub 2019 Aug 8.
3
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.耐甲氧西林金黄色葡萄球菌：分子特征、进化与流行病学。
Clin Microbiol Rev. 2018 Sep 12;31(4). doi: 10.1128/CMR.00020-18. Print 2018 Oct.
4
Genomic Basis for Methicillin Resistance in Staphylococcus aureus.金黄色葡萄球菌耐甲氧西林的基因组基础。
Infect Chemother. 2013 Jun;45(2):117-36. doi: 10.3947/ic.2013.45.2.117. Epub 2013 Jun 26.
5
Isolation of methicillin-resistant coagulase-negative staphylococci from chickens.从鸡中分离耐甲氧西林凝固酶阴性葡萄球菌。
J Clin Microbiol. 1996 Sep;34(9):2072-7. doi: 10.1128/jcm.34.9.2072-2077.1996.
6
Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus.femB对金黄色葡萄球菌耐甲氧西林及肽聚糖代谢的影响
J Bacteriol. 1993 Mar;175(6):1612-20. doi: 10.1128/jb.175.6.1612-1620.1993.
7
Differential methicillin susceptibilities of peptidoglycan syntheses in methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌中肽聚糖合成的甲氧西林敏感性差异
J Bacteriol. 1981 Nov;148(2):610-7. doi: 10.1128/jb.148.2.610-617.1981.
8
Detection of oxacillin-resistant staphylococci by the AutoMicrobic system.使用自动微生物系统检测耐苯唑西林葡萄球菌。
J Clin Microbiol. 1983 Nov;18(5):1205-11. doi: 10.1128/jcm.18.5.1205-1211.1983.
9
Rapid recognition of methicillin-resistant Staphylococcus aureus by use of automated test systems.使用自动化检测系统快速识别耐甲氧西林金黄色葡萄球菌。
J Clin Microbiol. 1984 Sep;20(3):430-3. doi: 10.1128/jcm.20.3.430-433.1984.
10
Increase in transduction efficiency of Tn551 mediated by the methicillin resistance marker.由甲氧西林抗性标记介导的Tn551转导效率的提高。
J Bacteriol. 1983 Apr;154(1):533-5. doi: 10.1128/jb.154.1.533-535.1983.
本文引用的文献
1
Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain.金黄色葡萄球菌中耐甲氧西林的转导取决于受体菌株的异常特异性。
J Bacteriol. 1970 Dec;104(3):1158-67. doi: 10.1128/jb.104.3.1158-1167.1970.
2
Transduction of staphylococcal enterotoxin B synthesis: establishment of the toxin gene in a recombination-deficient mutant.葡萄球菌肠毒素B合成的转导：毒素基因在重组缺陷型突变体中的建立。
Infect Immun. 1980 Jan;27(1):280-2. doi: 10.1128/iai.27.1.280-282.1980.
3
Transduction of methicillin resistance in Staphylococcus aureus: recipient effectiveness and beta-lactamase production.金黄色葡萄球菌中耐甲氧西林的转导：受体效能与β-内酰胺酶的产生
Antimicrob Agents Chemother. 1980 Sep;18(3):424-32. doi: 10.1128/AAC.18.3.424.
4
Extrachromosomal control of methicillin resistance and toxin production in Staphylococcus aureus.金黄色葡萄球菌中耐甲氧西林和毒素产生的染色体外控制
J Bacteriol. 1969 May;98(2):351-8. doi: 10.1128/jb.98.2.351-358.1969.
5
Effects of ethidium bromide on growth and on loss of the penicillinase plasmid of Staphylococcus aureus.溴化乙锭对金黄色葡萄球菌生长及青霉素酶质粒丢失的影响。
J Bacteriol. 1971 Dec;108(3):1200-4. doi: 10.1128/jb.108.3.1200-1204.1971.
6
Genetic analysis of methicillin-resistant strains of Staphylococcus aureus; evidence for their evolution from a single clone.耐甲氧西林金黄色葡萄球菌菌株的遗传分析；其源自单一克隆的进化证据。
J Med Microbiol. 1973 Nov;6(4):511-26. doi: 10.1099/00222615-6-4-511.
7
Absence of circular plasmid deoxyribonucleic acid attributable to a genetic determinant for methicillin resistance in Staphylococcus aureus.金黄色葡萄球菌中耐甲氧西林的遗传决定因素导致环状质粒脱氧核糖核酸缺失。
J Bacteriol. 1973 Nov;116(2):771-7. doi: 10.1128/jb.116.2.771-777.1973.
8
Transformation analysis of three linkage groups in Staphylococcus aureus.金黄色葡萄球菌三个连锁群的转化分析
J Bacteriol. 1975 Oct;124(1):201-11. doi: 10.1128/jb.124.1.201-211.1975.
9
Chromosomal map location of the methicillin resistance determinant in Staphylococcus aureus.金黄色葡萄球菌中耐甲氧西林决定簇的染色体图谱定位。
J Bacteriol. 1978 Aug;135(2):460-5. doi: 10.1128/jb.135.2.460-465.1978.
10
Mutations in prophage phi11 that impair the transducibility of their Staphylococcus aureus lysogens for methicillin resistance.噬菌体phi11中的突变会损害其金黄色葡萄球菌溶原菌对甲氧西林耐药性的转导能力。
J Bacteriol. 1977 Jan;129(1):237-45. doi: 10.1128/jb.129.1.237-245.1977.
Zotero 插件