Gorden P, Carpentier J L, Freychet P, Orci L
J Histochem Cytochem. 1980 Aug;28(8):811-7. doi: 10.1177/28.8.6255030.
Polypeptide hormones, growth factors, and a variety of other naturally occurring ligands bind specifically to receptors on the cell surface. At physiologic temperatures these ligands are internalized by cells and associate intracellularly with lysosomes. Receptor-mediated internalization provides a simple mechanism that may act to couple receptor-mediated hormone degradation with receptor-medicated receptor regulation.
多肽激素、生长因子以及多种其他天然存在的配体可特异性结合细胞表面的受体。在生理温度下，这些配体被细胞内化，并在细胞内与溶酶体结合。受体介导的内化作用提供了一种简单的机制，该机制可能将受体介导的激素降解与受体介导的受体调节联系起来。
