Sheffield W D, Strandberg J D, Braun L, Shah K, Kalter S S
J Infect Dis. 1980 Oct;142(4):618-22. doi: 10.1093/infdis/142.4.618.
Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were positive for antigen of simian virus 40 by immunoperoxidase staining of paraffin sections of affected organs. Electron microscopy revealed characteristic papovarirus particles in these tissues. This study is the first report indicating that simian virus 40 may produce pulmonary and renal disease in its natural host.
猴空泡病毒40是从一只死于自然获得性间质性肺炎和肾小管坏死的成年恒河猴中分离出来的。光学显微镜检查显示，肺和肾中的病变与嗜碱性核内包涵体有关。通过对受影响器官石蜡切片进行免疫过氧化物酶染色，这些包涵体对猴空泡病毒40抗原呈阳性反应。电子显微镜检查发现这些组织中有特征性的乳头多瘤空泡病毒颗粒。本研究首次报告表明，猴空泡病毒40可能在其自然宿主中引起肺部和肾脏疾病。
