Keller E, Cummins J T
J Neurochem. 1980 Dec;35(6):1329-34. doi: 10.1111/j.1471-4159.1980.tb09006.x.
The increased levels of NAD(P)H effected by electrical depolarization are markedly augmented in the presence of cyclic AMP, isoproterenol, or RO 20-1724, agents known to elevate cyclic AMP in rat brain slices. The data presented indicate that the cyclic AMP effect on an important component of intermediate metabolism is not an enhancement of a basal response but a separate response that is activated by depolarization, is Ca2+-dependent, regulates cytochrome a-a3 independently of its effects on NAD(P)H levels, and is dependent on a substrate other than glucose.
电去极化所影响的NAD(P)H水平升高，在存在环磷酸腺苷（cAMP）、异丙肾上腺素或RO 20 - 1724（已知可提高大鼠脑片中环磷酸腺苷水平的试剂）的情况下会显著增强。所呈现的数据表明，环磷酸腺苷对中间代谢一个重要成分的影响并非增强基础反应，而是一种由去极化激活的独立反应，它依赖于Ca2+，独立于其对NAD(P)H水平的影响来调节细胞色素a - a3，并且依赖于除葡萄糖以外的一种底物。
