Gant N F, Worley R J, Everett R B, MacDonald P C
Kidney Int. 1980 Aug;18(2):253-8. doi: 10.1038/ki.1980.133.
Normal human pregnancy is characterized by vascular refractoriness to AII. This pregnancy-induced vascular refractoriness appears to be mediated principally by decreased vascular smooth muscle responsiveness to AII rather than by alterations in blood volume or plasma concentrations of renin or AII. The mechanism that controls vascular refractoriness during normal pregnancy likely involves a localized prostaglandin or prostaglandin-like action mediated through cyclic nucleotides. The action of progesterone or one of its metabolites appears to mediate the synthesis or the catabolism of locally produced prostaglandins or prostaglandin-like agents.
正常人类妊娠的特征是血管对血管紧张素II（AII）产生不应性。这种妊娠诱导的血管不应性似乎主要是由血管平滑肌对AII的反应性降低介导的，而不是由血容量或肾素或AII的血浆浓度改变介导的。正常妊娠期间控制血管不应性的机制可能涉及通过环核苷酸介导的局部前列腺素或类前列腺素作用。孕酮或其代谢产物之一的作用似乎介导了局部产生的前列腺素或类前列腺素物质的合成或分解代谢。
