Mozhaeva G N, Naumov A P
Neirofiziologiia. 1980;12(6):619-26.
The kinetics of the scorpion Buthus eupeus venom toxin binding to sodium channels at holding potential -120 mV and subsequent dissociation of the toxin-channel complex with the membrane potential shifts to -60 divided by +120 mV were studied under voltage clamp conditions in the Ranvier node membrane. The dissociation rate is shown to increase exponentially when shifting the membrane potential towards more positive values, with an e-fold increase for each 32.3 mV. The results are consistent with the suggestion that the dissociation of the toxin-channel complex is due to a difference in electric energy between normal and toxin-modified inactivated sodium channels.
在电压钳制条件下，研究了以色列金蝎毒液毒素在-120 mV钳制电位下与钠通道的结合动力学，以及随后随着膜电位从-60 mV变化到+120 mV时毒素-通道复合物的解离情况。结果表明，当膜电位向更正的值变化时，解离速率呈指数增加，每32.3 mV增加一倍。这些结果与毒素-通道复合物的解离是由于正常和毒素修饰的失活钠通道之间电能差异的观点一致。
