George B, Techenet J, Porta M
Neurochirurgie. 1980;26(1):51-3.
Levels of 3' 5' AMPc in CSF were analysed by radioimmunoassay in 56 patients. 12 were used as control and 33 had a Subarachnoid Haemorrage (SAH) between 1 and 22 days before sampling. Out of these 33 cases, 20 had an arterial aneurysm, 7 showed a more or less relevant degree of vasospasm on arteriography. 11 other patients presenting different neurological diseases were studied for comparison. (Ischemia, Hydrocephalus, Atrophy, Hematoma). 3' 5' AMPc level in CSF was found to be very low in case of SAH, especially in patients harboring a definite vasospasm. The significance of AMPc level in CSF is discussed in relation with impairment of consciousness, spasm, ischemia, cortical atrophy, hydrocephalus and hematoma.
采用放射免疫分析法对56例患者脑脊液中3',5'-环磷酸腺苷（3' 5' AMPc）水平进行了分析。其中12例作为对照，33例在采样前1至22天发生了蛛网膜下腔出血（SAH）。在这33例病例中，20例有动脉瘤，7例在动脉造影中显示出不同程度的血管痉挛。另外研究了11例患有不同神经系统疾病（缺血、脑积水、萎缩、血肿）的患者以作比较。发现SAH患者脑脊液中3' 5' AMPc水平非常低，尤其是在有明确血管痉挛的患者中。结合意识障碍、痉挛、缺血、皮质萎缩、脑积水和血肿讨论了脑脊液中3' 5' AMPc水平的意义。
