肾上腺糖皮质激素对肌肉糖原分解的允许性调节：对蛋白磷酸酶及其抑制剂的作用。
Adrenal glucocorticoid permissive regulation of muscle glycogenolysis: action on protein phosphatase(s) and its inhibitor(s).
作者信息
Green G A, Chenoweth M, Dunn A
出版信息
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5711-5. doi: 10.1073/pnas.77.10.5711.
Adrenal glucocorticoids exert a permissive action on the glycogen phosphorylase cascade. Epinephrine activation of muscle phosphorylase and phosphorylase b kinase is depressed in adrenalectomized rats. Phosphorylase phosphatase activity is increased by steroid lack, and normal epinephrine inhibition of the enzyme does not occur. Phosphorylase b kinase phosphatase activity is also increased; epinephrine, however, does not inhibit activity in muscle from normal or adrenalectomized rats. Protein phosphatase inhibitor activity is depressed in boiled dialyzed preparations made from adrenalectomized rat muscle. Cortisol resplacement therapy restores protein phosphatase inhibitor activity, decreases increased protein phosphatase activity, and restores normal epinephrine-induced activation of phosphorylase b kinase and phosphorylase and epinephrine inhibition of phosphorylase phosphatase.
肾上腺糖皮质激素对糖原磷酸化酶级联反应具有允许作用。在肾上腺切除的大鼠中，肾上腺素对肌肉磷酸化酶和磷酸化酶b激酶的激活作用受到抑制。类固醇缺乏会增加磷酸化酶磷酸酶的活性，且正常情况下肾上腺素对该酶的抑制作用不再出现。磷酸化酶b激酶磷酸酶的活性也会增加；然而，肾上腺素对正常或肾上腺切除大鼠肌肉中的该活性并无抑制作用。肾上腺切除大鼠肌肉制成的煮沸透析制剂中，蛋白磷酸酶抑制剂活性降低。皮质醇替代疗法可恢复蛋白磷酸酶抑制剂活性，降低增加的蛋白磷酸酶活性，并恢复正常的肾上腺素诱导的磷酸化酶b激酶和磷酸化酶激活以及肾上腺素对磷酸化酶磷酸酶的抑制作用。
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