美替吡酮对雄性印度巨松鼠（Funambulus pennanti (Wroughton)）垂体的影响。

Effect of metopirone on pituitary gland of male squirrel, Funambulus pennanti (Wroughton).

Bhiwgade D A, Gulhane L T

Z Mikrosk Anat Forsch. 1980;94(3):451-9.

Abstract

The ACTH cell type has been demonstrated for the first time in the hypophysis of the squirrels. These are large cells with homogenous cytoplasm and are more abundant in the anteromedian zone and in the peripheral portion than elsewhere. 2. A great hypertrophy and hyperplasia of the pituitary corticotrophs were observed in the experimental group at all the intervals. 3. Metopirone treated animals showed a moderate hypertrophy and degranulation of pituitary thyrotrophs. 4. By effect of metopirone, a marked regression of pituitary interstitiotrophs and total degranulation took place by 30 days treatment. The folliculotrophs did not show alterations.

摘要

促肾上腺皮质激素（ACTH）细胞类型首次在松鼠的垂体中得到证实。这些是具有均匀细胞质的大细胞，在前正中区和周边部分比其他部位更为丰富。2. 在实验的各个时间段，实验组均观察到垂体促肾上腺皮质激素细胞显著肥大和增生。3. 甲吡酮处理的动物垂体促甲状腺激素细胞出现中度肥大和脱粒。4. 受甲吡酮作用，经30天治疗后，垂体促间质激素细胞显著消退并完全脱粒。促卵泡激素细胞未显示出变化。