胎儿垂体移植能够在切除正中隆起的成年大鼠中启动激素合成。

Fetal pituitary graft is capable of initiating hormone synthesis in median eminence removed adult rat.

作者信息

Nemeskéri A, Sétáló G, Kacsóh B, Halász B

机构信息

2nd Department of Anatomy, Semmelweis Medical University, Budapest, Hungary.

出版信息

Endocrinol Exp. 1990 Sep;24(3):283-92.

PMID:2171902

Abstract

Rathke's pouches of 12- and 13-day-old rat embryos were implanted beneath the kidney capsule of adult male rats subjected to the removal of median eminence or to sham-operation. Host animals were sacrificed 28 days after grafting and the implanted pituitaries were processed for immunohistological examination. ACTH, LH-beta, FSH-beta, TSH-beta, GH and PRL immunopositive cells could be observed in fetal grafts of all experimental groups. However, the number and staining intensity of different hormone containing cells largely varied and presumably depended on the hormonal state of host animals. The results indicate that undifferentiated fetal pituitary does not require hypothalamic hypophysiotrophic neurohormones for proliferation and cytodifferentiation and that its development might be modulated by circulating trophic hormones of host animals.

摘要

将12日龄和13日龄大鼠胚胎的拉特克囊植入成年雄性大鼠的肾被膜下，这些成年雄性大鼠已接受正中隆起切除或假手术。移植28天后处死宿主动物，将植入的垂体进行免疫组织学检查。在所有实验组的胎儿移植物中均可观察到促肾上腺皮质激素（ACTH）、促黄体生成素β亚基（LH-β）、促卵泡生成素β亚基（FSH-β）、促甲状腺激素β亚基（TSH-β）、生长激素（GH）和催乳素（PRL）免疫阳性细胞。然而，不同含激素细胞的数量和染色强度差异很大，可能取决于宿主动物的激素状态。结果表明，未分化的胎儿垂体在增殖和细胞分化过程中不需要下丘脑促垂体神经激素，其发育可能受宿主动物循环营养激素的调节。